Dangerous universal donors; II. Further observations on in vivo and in vitro behavior of isoantibodies of immune type present in group O blood.

By DONALD M. ERvIN, M.D., RICHARD M. CHRISTIAN, M.D., AND LAWRENCE E. YOUNG, M.D. H EMOLYTIC reactions resulting from transfusion of group 0 plasma into group A recipients, while not common, have been reported with increasing frequency during the past few years.’5 Reactions of this type are usually not as dramatic or as severe as those resulting from transfusion of incompatible whole blood and in all probability are frequently not detected clinically. The ease with which hemolytic transfusion reactions may be overlooked is best appreciated by realizing that they may occur without producing chills, fever, circulatory collapse, hack or flank pain, oliguria, hemoglobinuria or jaundice. #{176}